Topics:
Rheumatology • General Rheumatology • Scleroderma • Pulmonology • Mixed Connective Tissue Disease • SLE • Pulmonary Hypertension • Pulmonary Vascular Disease
How do you approach management of a patient with idiopathic PAH and +ANA, but no other current symptoms/signs of active rheumatologic disease?
Answer from: at Academic Institution
First, I'd collect specific antibodies we have for diseases that have PAH associations like SLE, Sjogrens, systemic sclerosis, and MCTD to make sure not to miss a diagnosis in addition to checking inflammatory markers and UA.
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Answer from: at Academic Institution
(1) Of note, abnormal nail fold capillaroscopy is associated with PAH in several systemic immune diseases: This is famously true for systemic sclerosis, but there are also publications reporting this association for other diseases, notably those in the “lupus family“ like SLE and dermato...
Answer from: at Academic Institution
If all ANA sub-serology is negative: it's important to look at BMI, OSA, etc.