How do you approach patients with advanced resectable basal cell carcinoma for possible use of hedgehog inhibitors?

Hello, @Dr. First Last! If surgically resectable, then surgery. If a response to hedgehog inhibitors will reduce the morbidity of the surgery, then I would give one as tolerated (good responses seen within 3 months).

Fosko et al., PMID 31836564

Kahana et al., PMID 33988881

Dear Dr. @Dr. First Last, we avoid hedgehog inhibitors in our practice due to several side effects. For head and neck BCC, our experience with first line checkpoint inhibitors has been great in reducing the tumor burden. The patients have not gone to surgery so far as was planned before due to the r...