How do you approach the treatment for locally advanced gastric adenosquamous carcinoma following D2 resection?

As you suggested, there is a paucity of prospective data for gastric adenosquamous carcinomas (ASC). Some retrospective works (see Sci Rep 7, 4597 (2017)) have suggested higher T-stage, more nodal involvement, and worse prognosis, when compared to traditional adenocarcinomas. Whether or not this rep...

Prospective data will not be available. In the absence of better clinical or molecular guidance, I will treat such patients same way I treat adenocarcinomas.