How do you approach the treatment of UC with PSC and how do you position oral vancomycin against biologic therapies?

A number of case reports have suggested that oral vancomycin improved the course of PSC, but more rigorous clinical trials have failed to confirm the benefits. [Deneau et al., PMID 32946600. Assis & Bowlus., PMID 37084929]

The treatment of neither UC nor PSC seems to affect the other condition. That ...

Vancomycin is not really helpful for treating either PSC or ulcerative colitis. Pateients with both diseases respond well to biologic therapy for the ulcerative colitis because ulcerative colitis in patients with PSC, tends to be less severe.