How do you decide between Nivolumab + Ipilimumab and Pembrolizumab or Nivolumab monotherapy in later lines of MSI-H Colorectal cancer?

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For a MSI-high colon cancer patients already treated with FOLFOX, FOLFIRI and appropriate antibodies, what is your regimen of choice?

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1 Answer

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Medical Oncology · Rutgers Cancer Institute of New Jersey

Answered on

The data are fairly clear that patients with the combination of nivolumab and ipilimumab is highly active based on the Checkmate-142 study (Overman, et al, JCO 36, no. 8 (March 10 2018): 773-779, 2018) showing a 55% RR with 5% CR (n=119 patients, all post at least 2 prior chemo regimens). PFS at 12 ...

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