How do you define bulky disease for Hodgkin's lymphoma which is outside the mediastinum?

Topics: Hematologic Malignancies • Radiation Oncology • Pediatric Oncology • Hodgkin Lymphoma • Hematology

Do you use a cutoff of 10 cm? Do you measure the size of the largest node or measure the largest conglomerate or measure the total length of the entire involved chain (i.e. in a patient that has numerous involved nodes extending from axilla up to supraclavicular region)?

Answer from: Radiation Oncologist at Community Practice

Definition of bulk in lymphoma is not homogenous among countries, study groups, and diseases.Overall, 10 cm is considered the cutoff by some. Recently, the cutoffs of 7 or 7.5 cm have been introduced, especially in DLBCL. The definition tends to be disease-specific sometimes, since landmark stu...

Comments

at John Theurer Cancer Center Hackensack Univ Med Center
How did they derive the cutoffs?

Radiation Oncologist at University Hospital Basel
These cutoffs are generally products of retrospect...

at University of Toronto
Is it not true that the measurement is in the axia...

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