How do you incorporate high-dose chemotherapy with autologous stem cell rescue for a patient with relapsed, metastatic Ewing sarcoma?

There are older single-arm studies indicating that incorporating autologous transplant into the treatment of relapsed Ewing sarcoma can lead to a 20-30% survival rate. Usually, a patient receives up to 3-5 rounds of reinduction with standard chemotherapy, followed by consolidation with autotransplan...

I agree. I have transplanted over years 8-10 transplants in this situation. A couple of them actually before relapse. To begin with, they were metastatic and bad prognostic, 3 of them who were transplanted in CR3 are all long term survivors.

I think the role of transplant is more (increased success...