How do you interpret NCCN chemoRT dose recommendations for SCLC which start higher than NSCLC?

Topics: Radiation Oncology • Thoracic Malignancies

Dose recommendations for NSCLC are to use at least 60 Gy, but for SCLC recommendations are for higher doses starting at 66 Gy.

Classically, SCLC is more radiosensitive and thus would be the histology with the slightly lower dose range. Are we constrained by the trials that have been performed?

Answer from: Radiation Oncologist at Academic Institution

I understand the questioner's logic that because SCLC is traditionally considered more radiosenstive than NSCLC, it may seem discordant that guidelines recommend 66Gy for SCLC but 60Gy for NSCLC. However, I would still abide by these guidelines because as the questioner suggests, these doses are bas...

Comments

Radiation Oncologist at Cancer Care Centers of Brevard
Bogart et al. CALGB/RTOG study showed equivalence ...

Related Questions