How do you manage a T1N0 well differentiated anal margin squamous cell carcinoma with low-grade dysplasia at the surgical margin who has already undergone re-excision and is not eligible for further excision without an APR?

There is absolutely no role for the adjuvant treatment of carcinoma in situ or dysplasia in anal margin squamous cell carcinoma. The reasons for this are that 1) This is not cancer. The patient will live a long time. If you cause any long-term effects in a person who does not have cancer such as pai...