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Topics:
Breast Cancer
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Medical Oncology
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NCI-CCC Tumor Board Question
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Yale
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HR+
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NCI-CCC Breast Tumor Board Question
How do you manage adjuvant endocrine therapy for microinvasive HR-positive disease measuring >=1mm in extension?
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For patients with metastatic HER2-null (IHC 0+) breast cancer, do you offer trastuzumab deruxtecan based on the DAISY trial results?
In light of SABCS 2022, when will you opt for a CDK 4/6 inhibitor plus AI instead of chemotherapy in patients with metastatic HR-positive HER2-negative breast cancer with visceral crisis?
How do you approach initial treatment of unresectable, locally advanced ER+, HER2-negative male breast cancer?
In what circumstances would you stop therapy for patients with metastatic HER2+ breast cancer with long-term complete response to HER2-directed therapy?
In light of SABCS 2022, will you use BCI to guide OFS recommendation in the adjuvant setting?
In which situations do you offer ovarian suppression with chemotherapy to prevent the development of premature menopause in premenopausal women with ER negative breast cancer?
Would you offer capecitabine re-challenge for a patient with metastatic breast cancer and a history of coronary vasospasm?
What is your preferred adjuvant chemotherapy regimen for a patient with local recurrence of TNBC two years after completing neoadjuvant ddAC-T who declined prior adjuvant capecitabine?
Is there evidence for development of more severe autoimmune toxicities for young patients vs older patients on immune checkpoint inhibitors?
Would you recommend axillary lymph node dissection in a pre-menopausal woman with ER+ PR+ HER2- IDC, s/p lumpectomy and SLN with pT1c pN1 cM0 disease, where 2 sentinel nodes are positive for macrometastasis and 1 SN is positive for micrometastasis?