Yale   

Questions discussed in this category



Patient is young. Bilirubin normalizes when tucatinib is held, but again increases to grade 2 when it is restarted. Evaluation for hemolysis was negat...

Do you routinely offer post-operative adjuvant radiation in addition to chemotherapy?  Are the results of the recently published negative phase ...

Patient underwent mastectomy for DCIS in the setting of previous lumpectomy and adjuvant radiation for the invasive breast cancer. 

Is there any role for denosumab? How do you counsel patients regarding the benefit of bisphosphonates on breast cancer outcomes?

Ampullary carcinoma is not in the NCCN guidelines. Please address not only the role for therapy but the optimal regimen (i.e. Gem based, vs mFOLFIRINO...

I am considering every 6 week pembrolizumab dosing in patients >70 years old in whom I want to reduce clinic visits for, especially in the context ...

Is adjuvant radiation and/or adjuvant chemotherapy indicated? 

In a patient who is not a surgical candidate, do you offer concurrent carbo/taxol rather than 5FU/oxaliplatin? 

For a patient with high risk disease and a severe enough reaction that additional taxane-based therapy is contraindicated, do you consider alternate c...

Should staging and treatment decisions be made based on imaging alone?

When would you favor delivering local therapy (e.g. SBRT) prior to systemic therapy?

Would you treat this as a locally advanced breast cancer and offer surgery, radiation, and systemic therapy? Does your management change depending on ...

These patients have been largely excluded from these trials.  What if the infection is well controlled?

Would you offer adjuvant TKI following ADAURA data?  Or proceed with durvalumab based on PACIFIC data?


Papers discussed in this category


Breast Cancer, 2012 Apr 25

Annals of surgical oncology, 2018-10

Lancet Oncol., 2015 Sep 09

BMJ, 2016 Sep 30

The New England journal of medicine, 2016-08-25

The New England journal of medicine, 2018-07-12

Journal of the National Cancer Institute, 2017-02

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-04-10

The Lancet. Oncology, 2012-07

Annu. Rev. Med., 2015 Aug 28

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-06-20

Lancet,

Lancet Oncol, 2019 Feb 19

Lancet Oncol, 2019 Dec 02

Lancet Oncol, 2017 Oct 13

JNCI Cancer Spectr, 2021 May 28

J. Clin. Oncol., 2018 Jun 15

The Lancet. Oncology, 2015-02

J. Clin. Oncol., 2017 Dec 14

The New England journal of medicine, 2018-12-13

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-01

Arch Surg,

Lancet, 1998 Jul 25

Int. J. Radiat. Oncol. Biol. Phys., 2008-11-01

JAMA Oncol,

Lancet Oncol, 2021 Dec 15

JAMA, 2012 Jul 11

Radiation oncology (London, England), 2011-09-28

JAMA surgery, 2019-05-29

Clin Transl Oncol, 2018 Mar 28

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2003-03-15

N. Engl. J. Med.,

Breast, 2013 Dec 22

Breast, 2015 Oct 09

Cancer, 2011-11-01

Case reports in oncology, 2017

BMC Cancer, 2015 Oct 15

Lancet Oncol., 2015-09-01

J. Thorac. Cardiovasc. Surg.,

Cancer, 2015 Jan 06

Eur J Cardiothorac Surg,

British journal of cancer, 2011-06-07

N Engl J Med, 2021-04-01

Clin Imaging, 2021 Feb 10

J Clin Oncol, 2022 Jan 18

The New England journal of medicine, 2011-06-23

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2014-05-10

Lancet, 2019 Dec 12

Lancet (London, England), 2016-02-27

N. Engl. J. Med., 2017 Jun 04

The New England journal of medicine, 2018-08-23

Breast Cancer Res Treat, 2016 Feb 18

Mol Cancer Ther, 2018 Mar 28

Eur J Cancer, 2014 Aug 12