How do you manage early stage uterine carcinosarcoma?

Unfortunately, no good prospective study has shown an impact on survival with any adjuvant treatment. Based on relapse patterns at our institution for surgically staged IA disease, it is chemotherapy (ifosfamide plus taxol) plus cuff brachy. For all other stages, it is usually chemo as above followe...

Uterine carcinosarcomas are rare and considered high-risk variants of endometrial cancer which has a high chance of distant metastasis.

There is no randomized trial of adjuvant treatment in stage I and II of carcinosarcoma alone except GOG #150 (stage I-IV). GOG #20 with stage I and II uterine sarcom...

Depends on what you mean by early stage.

If you mean IA, NCDB suggests that for unfavorable histology (and for carcinosarcoma histology), chemotherapy and BT may help significantly, while EBRT may not. Seen regardless of whether is an endometrial polyp or < 50% MMI. Standard caveats of NCDB analyses:...