How do you manage new brain metastases in patients on trastuzumab emtansine (TDM-1) who has controlled extracranial disease?
A case series from Colorado raises concern over significant radiation necrosis with SRS. However, there doesn't seem to be much additional negative literature available. In fact, some whole brain reports seem positive. Is a break necessary prior to radiation? For multiple metastases, would SRS or whole brain be preferred?
1 Answer
Mednet Member
Radiation Oncology · Karmanos Cancer Institute - McLaren Proton Therapy Center
Answered on
This is an increasingly common clinical scenario, because systemic control with antibodies is quite good, but HER2+ disease still has a strong predilection for the brain. There is a third treatment option here, which may have lower toxicity than either whole brain or SRS.
Particularly where larger vo...
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