Topics:
Breast Cancer • Medical Oncology
How do you monitor ovarian function in high risk, premenopausal breast cancer patients receiving adjuvant ovarian suppression?
What is the ideal timing for monitoring and what laboratory tests should be used?
Answer from: Medical Oncologist at Community Practice
Great question. Extremely clinically relevant. Here's the problem with 'medical oophorectomy': ABCSG-12 showed that OFS+AI in premenopausal women who were overweight had a 50% increased risk for disease recurrence. SOFT trial sub-study, SOFT-EST, showed that one in three women on OFS+AI have subopti...
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Answer from: Medical Oncologist at Academic Institution
Ideal is not known. I typically measure estradiol trough levels after 3 months of ovarian suppression. About 15% of premenopausal women do not get adequate ovarian suppression with monthly GNRH agonists.
If estradiol is detected, then I might go an additional month and recheck. &...
Comments
Medical Oncologist at Tennessee Oncology - Nashville
Thanks for your insight. For alternative means to ...
Thanks for your insight. For alternative means to ...