How do you select the concurrent cisplatin dose and schedule when treating locally advanced endometrial cancer with chemoradiation?
If a weekly schedule is chosen, what would be the appropriate weekly dose given that PORTEC-3 and GOG 258 used two cycles of cisplatin 50 mg/m2?
2 Answers
Mednet MemberInvited Expert
Radiation Oncology · Varian Medical Systems/Allegheny health network
Answered on
For locally advanced endometrial cancer treated with pre operative or definitive intent, we use weekly cisplatinum at 40mg/m2.
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Mednet MemberInvited Expert
Gynecologic Oncology · Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Answered on
Just like @Dr. First Last, for most patients, I give cisplatin 40mg/m2 weekly as a radiosensitizer for definitive chemo radiation in uterine cancer. If the patient has poor renal function or is frail, then I will typically give carboplatin AUC 2 weekly.
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