How do you select the concurrent cisplatin dose and schedule when treating locally advanced endometrial cancer with chemoradiation?

Topics: Radiation Oncology • Gynecologic Cancers

If a weekly schedule is chosen, what would be the appropriate weekly dose given that PORTEC-3 and GOG 258 used two cycles of cisplatin 50 mg/m2?

Answer from: Radiation Oncologist at Community Practice

For locally advanced endometrial cancer treated with pre operative or definitive intent, we use weekly cisplatinum at 40mg/m2. Vargo et al., PMID 25218303

Answer from: at Community Practice

Just like @Sushil Beriwal, for most patients, I give cisplatin 40mg/m2 weekly as a radiosensitizer for definitive chemo radiation in uterine cancer. If the patient has poor renal function or is frail, then I will typically give carboplatin AUC 2 weekly.

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