How do you treat a female with a diagnosis of invasive apocrine carcinoma of the breast?

While some data suggests that apocrine cancers may not respond as well to chemotherapy as ‘usual’ triple negative breast cancers, 80-90% are basal-like by gene expression analysis. I treat them the same way - with adjuvant chemotherapy for Stage I cancers (or Stage II-III patients who didn’t receive neoadjuvant chemo), with neoadjuvant chemotherapy including carboplatin for clinical Stage II-III cancers, with adjuvant capecitabine in patients with significant residual disease (RCB Class II-III) after neoadjuvant chemotherapy, and with chemotherapy for metastatic disease. I would consider anti-androgen therapy (bicalutamide, enzalutamide - if you can get it on compassionate use, given its cost - or a clinical trial of a similar agent) in a p...