How do you treat diffuse large B cell lymphoma (DLBCL) in a patient with cirrhosis complicated by thrombocytopenia?
How would your approach differ between limited stage and advanced stage DLBCL?
Would your approach differ between compensated and decompensated cirrhosis?
Would concurrent cytopenias related to cirrhosis/splenomegaly alter your recommendations?
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Mayo Clinic Jacksonville
Answered on
Thank you for the question. This is a very challenging case. There are different factors to consider, such as age, PS, stage, and actual liver function. Liver function may have been affected by lymphoma.
Most likely, the patient will require dose reductions of standard R-CHOP (such as mini R-CHOP). A...
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