How do you treat leptomeningeal disease in metastatic HR+ HER2- breast cancer?
The patient is treatment naïve and asymptomatic. She also has disease in the body (bone and liver metastases).
1 Answer
Mednet MemberInvited Expert
Medical Oncology · Ellison Institute, LLC
Answered on
Survival after a diagnosis of leptomeningeal metastasis (LM) remains poor. Radiation therapy remains a primary therapy for breast cancer LM. Intrathecal therapy has resulted in limited efficacy and is associated with significant toxicity. Limited data regarding the efficacy of systemic therapies in ER+ breast cancer LM exists.
At SABCS 2018, Tolaney et al (publication P1-19-01) presented a phase 2 study of abemaciclib in patients with HR+ breast cancer LM. A total of 7 patients with HR+ LM were e...
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