How do you utilize PRAME for melanocytic biopsies?

PRAME is useful as one piece of information to help me decide if I have enough criteria for melanoma in situ. Like most IHC stains it is just a piece of the puzzle to me. In my experience, positivity of MIS is about 7-8/10, so I do not require PRAME positive to diagnose MIS. But positive PRAME helps...