How does number of ITC influence your approach to adjuvant RT for a surgically staged 1B endometrial cancer meeting HIR criteria?

Management of ITC only in the setting of SNLN is not defined well.

We know ITC has a much better prognosis than micromets and macromets.

We also know that even with ITC after SNLN bx only, there is risk of additional residual nodal disease left behind which may need to be addressed.

What we don’t k...

While the presence of ITCs alone does not change my practice, I try to look at that in the context of the big picture. The first thing that I do is to make sure the pathology diagnosis is correct which sometimes leads me to get a second review on the pathology. If this were upstaged to micromets, th...

With or without the ITC's, this patient is categorized as high intermediate risk per GOG 249 (age 73, with at least one risk factor--deep invasion, and positive LVSI). Given this alone, she would merit post operative adjuvant radiation therapy. Given the MELF and ITC, I would advocate for pelvic RT ...