How does your management of stomatitis from Dato-DXd compare to your approach for stomatitis from other cancer-directed treatments?

By and large, the treatment is similar, though dexamethasone rinses are essential (10 mL oral solution, 4 times a day). Patients should swish/gargle the steroid solution for 1-2 minutes, then spit it out. Food and drink should be avoided for 30 minutes afterward. Similarly, patients should avoid cau...

While management principles are similar to other agents known to cause stomatitis (such as everolimus), what distinguishes Dato-DXd is how frequently the stomatitis happens, and why prophylactic steroid mouthwash is essential.

In line with the package label and guideline recommendations, I do recommend prophylactic use of steroid mouthwash for stomatitis prevention and management with Dato-DXd, similar to my practice with mTOR inhibitors (everolimus). This is different from an agent like capecitabine, where I would utiliz...

Agree with the preventative measures discussed. Would add:

• Mucositis tends to happen early (2-3 weeks) upon starting therapy, which argues for early implementation of preventative measures.
• Mucositis caused by Dato-DXd can last weeks.
• I add Clotrimazole lozenges to steroid rinses, especially when u...