How does your management of stomatitis from Dato-DXd compare to your approach for stomatitis from other cancer-directed treatments?

By and large, the treatment is similar, though dexamethasone rinses are essential (10 mL oral solution, 4 times a day). Patients should swish/gargle the steroid solution for 1-2 minutes, then spit it out. Food and drink should be avoided for 30 minutes afterward. Similarly, patients should avoid cau...

In line with the package label and guideline recommendations, I do recommend prophylactic use of steroid mouthwash for stomatitis prevention and management with Dato-DXd, similar to my practice with mTOR inhibitors (everolimus). This is different from an agent like capecitabine, where I would utiliz...

While management principles are similar to other agents known to cause stomatitis (such as everolimus), what distinguishes Dato-DXd is how frequently the stomatitis happens, and why prophylactic steroid mouthwash is essential.