How should Dato-DXd be managed in the absence of necessary resources for ocular exams and referrals?

We typically send patients for baseline slit-lamp exams prior to the start of Dato-DXd. If these resources are not available, telemedicine with slit-lamp biomicroscopic photography, as well as community screening resources, can be considered. Patients should still be educated on symptoms that would ...

Ocular surface events (OSE) included events such as dry eye, increased lacrimation, blurry vision, conjunctivitis, and keratitis in the Dato-DXd studies. In TROPION-PanTumor01, any grade OSEs occurred in 17 (41.5%) HR+/HER2- breast cancer (10 [24.4%] dry eye), 16 (36.4%) triple negative breast cance...

In an ideal world, baseline eye exams should be performed before starting treatment and completed every three treatment cycles thereafter. Annual ophthalmologic exams and ocular exams at the time of symptom onset are necessary. However, preventive/prophylactic measures can help to mitigate the toxic...