How will the removal of the clozapine REMS requirement change your clinical practice?

The recent developments in regards to the clozapine REMS program are steps in the right direction, to improve access to a very effective medication with a safer side effect profile than initially known. Hopefully, more psychiatrists will take the challenge of prescribing clozapine more once their co...

If they’ve been stable on it with stable ANC, I will start to do it every 3 months, then transition to 6 months. Agranulocytosis will happen in the first 3-6 months - it’s an immune-mediated reaction, so it’s going to happen sooner rather than later. After 6 months, you have as much chance of dying ...

In regards to side effects of clozapine - it can be in itself a barrier to treatment but if you know how to treat them it makes it so the patient will stay on it

Weight gain - metformin and I think in the future GLP-1 agonists may be the main go to for weight gain. Obviously the best treatment would...

I am hopeful that this will increase the prescribing of clozapine.