How would you approach a clinical stage 3 sigmoid colon cancer, dMMR/MSI-H with comorbidities and increased risk of surgical complications?

For patients with dMMR/MSI-H clinical stage III sigmoid colon cancer, the current practice would be upfront surgery, and usually, most patients should be able to tolerate the minimally invasive surgical approach.

If the patient is not a surgical candidate due to comorbidities with increased risk of ...