Colorectal Cancer   

Questions discussed in this category

Would presence of features considered high risk in stage II sway your interpretation of the IDEA trial? 

Do you use the same high risk factors as adenocarcinoma when deciding on adjuvant treatment for early stage disease?

In practice, does starting with chemoradiation followed by chemotherapy result in a significant delay in initiating chemotherapy or a patient's abilit...

The German trial included patients with tumors up to 16cm from the anal verge, while the Swedish trial update found no local control benefit for tumor...

Would you approach with curative intent with locoregional treatment or systemic treatment alone?

The NCCN seems to make its recommendation based on extrapolation from colon cancer, but those patients are not treated with pre-op chemoRT.

Has the utility of BRAF in CRC expanded beyond guiding prognosis? Is there a role in non-metastatic CRC?

If a patient with stage II or III colon adenocarcinoma who presents to your clinic 12-16 weeks after surgical resection do you give adjuvant chemother...

The RTOG contouring atlas doesn't give a consensus on this issue.

Is there a change in approach over the past few years? Would there be a role for the 12-gene recurrence score?

Since some prior subset analyses have suggested that oxaliplatin may not improve outcomes of older patients with colon cancer in the adjuvant settin...

Does the recent Hopkins trial of pembrolizumab change your management of these patients?

In a lesion <2.5 cm from anal verge arising in a tubulovillous adenoma, does the data from Taylor, et. al. Red Journal 2001 apply? 

The NCCN guidelines categorically recommend adjuvant XRT for a cT1-2N0 rectal adenocarcinoma upstaged to a pT3N0, yet there are multipl...

Should standard post operative radiation fields be used, treating up to the L5-S1 interspace? Or is it acceptable to treat a lower field, for ins...

In the past, I haven't seen great results in palliating the presacral area. The pain is excruciating for many patients. Is there an effective option f...

Papers discussed in this category

International journal of radiation oncology, biology, physics, 2001-11-01

Radiat Oncol, 2014-12-23

Lancet (London, England), 2009-03-07

J. Clin. Oncol., 2012-06-01

Br J Surg, 2006-10-01

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012-11-01

International journal of radiation oncology, biology, physics, 2014-03-15

Ann. Surg. Oncol., 2017 May 30

Ann. Oncol., 2019 Jun 13

Ann. Surg., 2007-11-01

Journal of cancer research and therapeutics, 2011

J Can Assoc Radiol, 1975-09-01

Int. J. Radiat. Oncol. Biol. Phys., 1995-01-15

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004-05-15

Diseases of the colon and rectum, 2008-08

JAMA oncology, 2018-06-14

J. Clin. Oncol., 2019 Oct 08

The New England journal of medicine, 1985-06-06


Eur J Surg Oncol,

Ann. Surg. Oncol., 2010 Sep 21

Clin Epidemiol, 2012 Nov 07

HPB : the official journal of the International Hepato Pancreato Biliary Association, 2016-03

Lancet Oncol., 2016-06-01

Nature, 2018-02-08

The Lancet. Oncology, 2019-04

Neuroendocrinology, 2019 Aug 21

Ann. Surg., 2019 Aug 30

Expert Opin Biol Ther, 2019 Mar 27

J. Clin. Oncol., 2019 Oct 14

N Engl J Med, 2015 Jun 25

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2018-03-10

N. Engl. J. Med., 2019 Sep 30

J. Clin. Oncol., 2019 May 31

British journal of cancer, 2011-02-01

Anticancer Res.,

Annals of surgical oncology, 2018-08