How would you approach definitive chemoradiation for node positive anal cancer with a history of ulcerative colitis status-post total proctocolectomy?

Topics: Radiation Oncology • Gastrointestinal Cancers

How would you adjust your small bowel dose constraints? What other considerations would be pertinent?

Answer from: Radiation Oncologist at Academic Institution

If there is no recent history of active colitis I do not change anything. If there is colitis with an intact rectum, I reduce the radiation dose by 10%. The toxicity and consequences of APR are worse than the toxicity of chemoradiation.

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Radiation Oncologist at Washington University School of Medicine
Besides the status of the inflammatory disease, th...

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