How would you approach potential SBRT to liver metastases in a patient on a VEGF inhibitor?

Topics: Radiation Oncology • Gastrointestinal Cancers • Stereotactic Body Radiotherapy • Medical Oncology • Liver and Pancreas Tumors

Would you alter your SBRT dose? How long would you hold the VEGF inhibitor before and after? Does the primary matter (e.g. NSCLC vs. colorectal)?

Answer from: Radiation Oncologist at Academic Institution

For patients who are on VEGF inhibitors, I would be very careful with dosing of radiation to nearby bowel and I discuss holding VEGF inhibitors for a time before, during and after radiation. There have been multiple reports of in field toxicity, particularly with respect to bowel (liver SBRT frequen...

Comments

Radiation Oncologist at UCLA | VA Greater Los Angeles Healthcare System
This is a great scenario in which to consider a tr...

Related Questions