How would you approach the primary treatment of a rapidly growing uterine carcinosarcoma with local extension through the anterior abdominal wall?
If considering systemic therapy, would you consider standard chemotherapy or use biomarker-directed therapy (e.g., imatinib if ckit+, larotrectinib/entrectinib if NTRK fusion identified, or immune checkpoint inhibitor if MSI, dMMR, TMB-H, or PD-L1+)?
Community PollStarted
How would you approach the primary treatment of a rapidly growing uterine carcinosarcoma with local extension through the anterior abdominal wall?
35 physicians have voted
Join Mednetto vote and see how they answered.
2 Answers
Mednet MemberInvited Expert
Medical Oncology · University of Florida College of Medicine
Answered on
This patient needs multimodal therapy - surgical resection is a mainstay of treatment followed by adjuvant therapy (most likely chemotherapy +/- vaginal brachytherapy). In terms of chemotherapy agents - up front adjuvant treatment is usually carboplatin/paclitaxel or ifosfamide/paclitaxel. I would p...
Join for free or sign in to see the full answer
Mednet Member
Radiation Oncology · Vanderbilt-Ingram Cancer Center
Answered on
Sounds like non-metastatic disease if it is all local growth. If resectable, take for upfront surgery followed by adjuvant therapy as appropriate.
If not immediately resectable and node negative, would generally recommend neoadjuvant RT +/- concurrent chemotherapy to shrink then take for surgery, fo...
Join for free or sign in to see the full answer