How would you approach therapy for a patient with high-grade sarcoma who is unable to tolerate systemic cytotoxic chemotherapy, but whose tumor revealed NRAS G12A, BRCA1, and MET amplification?

I would try weekly cisplatin.

Cisplatin is the best drug there is vs tumors with BRCA1 polymorphisms. You need reasonable kidney function for cisplatin but bad liver does not mean bad kidneys. Platinum is safe, with less hematologic toxicity than other chemos. You don't need a port. Weekly cisplatin...