How would you approach therapy for a SMARCA4-deficient undifferentiated sarcoma with isolated involvement of a mediastinal lymph node?

Topics: Sarcoma • Thoracic Malignancies • Medical Oncology

No primary thoracic mass identified. Knowing these often following an aggressive clinical course, would you consider concurrent chemo/RT, incorporate immunotherapy or advocate for surgery?

Answer from: Medical Oncologist at Academic Institution

This is a unique situation, but there is data to suggest that these thoracic tumors are actually sarcomatoid/de-differentiated carcinomas rather than true sarcomas. Rekhtman et al., PMID 31751681A smoking history or high tumor mutation burden on comprehensive genomic profiling would help with this d...

Comments

Medical Oncologist at Frederick Onc Hem Assoc
Thank you for your input.

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