Mednet Logo

What are the main practical factors to consider when using bispecific antibody therapy (Tarlatamab) for extensive-stage small cell lung cancer?

Community PollStarted

What process do you follow when managing a patient receiving tarlatamab (bispecific antibody therapy) for ES SCLC?

129 physicians have voted

Join Mednetto vote and see how they answered.

4 Answers
Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Colorado Anschutz Medical Center
Answered on · Updated on
The overall survival (OS) for patients with relapsed refractory small cell lung cancer is poor with an estimated OS of 8-9 months. Prior to DLL3 bispecifics, the 2nd line therapeutic options included topotecan and lurbinectidin. Topotecan always had an unusual positioning as a second line agent. The...

Join for free or sign in to see the full answer

Mednet Member
Mednet MemberInvited Expert
Medical Oncology · Indiana University
Answered on · Updated on

Tarlatamab is the newest FDA-approved therapy for relapsed SCLC. It received accelerated approval based on the DeLLphi-301 trial. Tarlatamab is a bispecific T-cell engager immunotherapy targeting delta-like ligand 3 and CD3. It has unique toxicities including CRS and ICANS and requires step-up dosin...

Join for free or sign in to see the full answer

Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University of Michigan
Answered on

Patient fitness, comorbidities, and toxicities to prior therapy. This is especially relevant as most patients will have received front line immunotherapy - however, the DeLLphi-301 protocol excluded patients who have a diagnosis of immunodeficiency and or are receiving systemic steroid therapy or im...

Join for free or sign in to see the full answer

Mednet Member
Mednet MemberInvited Expert
Medical Oncology · University Hospitals Seidman Cancer Center and Case Western Reserve University
Answered on

The main issue from my perspective is having the staff on knowing how to observe and treat potential side effects with the first 2 administrations. Knowledge of CRS symptoms, and not overreacting or underreacting are key issues. Other practical issues are bed and staff availability which can be a ma...

Join for free or sign in to see the full answer