What are the main practical factors to consider when using bispecific antibody therapy (Tarlatamab) for extensive-stage small cell lung cancer?
What process do you follow when managing a patient receiving tarlatamab (bispecific antibody therapy) for ES SCLC?
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Tarlatamab is the newest FDA-approved therapy for relapsed SCLC. It received accelerated approval based on the DeLLphi-301 trial. Tarlatamab is a bispecific T-cell engager immunotherapy targeting delta-like ligand 3 and CD3. It has unique toxicities including CRS and ICANS and requires step-up dosin...
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Patient fitness, comorbidities, and toxicities to prior therapy. This is especially relevant as most patients will have received front line immunotherapy - however, the DeLLphi-301 protocol excluded patients who have a diagnosis of immunodeficiency and or are receiving systemic steroid therapy or im...
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The main issue from my perspective is having the staff on knowing how to observe and treat potential side effects with the first 2 administrations. Knowledge of CRS symptoms, and not overreacting or underreacting are key issues. Other practical issues are bed and staff availability which can be a ma...
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