How would you consolidate a patient with primary refractory double hit lymphoma with secondary CNS involvement?

Thiotepa-based transplants are particularly rough. We haven't had good outcomes with them in terms of relapse and mortality is much higher than BEAM or Mel autos.

Having said that, this patient has chemo-refractory disease. The initial concern with CAR-T in primary CNS or secondary involvement was th...

I would extrapolate from the 2L CAR-T trials and will offer CAR-T therapy assuming that his CNS disease is relatively under control.