How would you counsel patients with Type 1 or Type 2 diabetes mellitus and heart failure on the use of SGLT-2 inhibitors when they have a history of DKA?

Making a recommendation to prescribe this class will really require a case-by-case clinical assessment. It is clear that SGLT-2 inhibitors are very effective in preventing hospitalization for heart failure, and so we will want to suggest their use whenever possible. But it is also clear that DKA (mo...