How would you manage a medically inoperable patient with an invasive squamous cell carcinoma of the oropharynx and extensive adjacent leukoplakia harboring pathologically-proven in situ disease?

How would you manage a medically inoperable patient with an invasive squamous cell carcinoma of the oropharynx and extensive adjacent leukoplakia harboring pathologically-proven in situ disease?

• Treat both the invasive and in situ disease to full-dose, including all areas of leukoplakia
• Treat both the invasive and in situ lesions, but treat the in situ portion to a lower dose to improve tolerability
• Treat only the invasive disease, refer the patient for superficial therapy to the in situ disease after XRT is complete
• Other