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Topics:
Hematologic Malignancies • Medical Oncology • Leukemia • Myeloproliferative Neoplasms • Hematology
How would you manage a patient with polycythemia with MPN symptoms (aquagenic pruritis, fatigue) that is JAK2/CALR/MPL negative but peripheral blood NGS positive for IDH2?
VUS is >50%. EPO level normal. How do you delineate between MPN with noncanonical mutation vs. CHIP incidental to polycythemia?