How would you manage a patient with primary CNS lymphoma who is not a candidate for high-dose methotrexate?  

In a patient who absolutely cannot receive chemotherapy due to impaired performance status, what dose would you use for WBRT and what dose would you use for a reduced field boost to the enhancing tumor volume (with margin)? 

Or, in such a situation, would palliative radiation therapy with WBRT to 30 Gy in 10 fractions be appropriate?

Answer from: Radiation Oncologist at Academic Institution