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How would you manage a patient with well-controlled HIV on Biktarvy, who is interested in switching to injectable HAART but also has a history of a prior Hepatitis B Infection?

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How would you manage a patient with well-controlled HIV on Biktarvy, who is interested in switching to injectable cabotegravir/rilpivirine, and has a history of prior Hepatitis B infection with an isolated anti-HBc antibody?

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2 Answers
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Infectious Disease · City of Hope Comprehensive Cancer Center
Answered on

HBV is a common co-infection in people with HIV (PWH), due to shared transmission routes. Two large meta-analyses of studies published found a global a pooled prevalence of HBV infection among PWH to be between 7.6 and 8.4%, with a higher prevalence in less developed countries (10.4%) compared to mo...

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Mednet Member
Mednet MemberInvited Expert
Infectious Disease · University of Texas Southwestern Medical School
Answered on · Updated on

I agree with the below; it is not typically recommended to switch to Cabenuva (cabotegravir + rilpivirine) in patients with active HBV infection (positive HBsAg), as it does not provide any coverage for this infection. If for some reason the patient wanted the Cabenuva and didn't mind taking some ex...

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