How would you manage recurrent laryngeal cancer after previous larynx xrt if surgical salvage not an option?

Re-RT for recurrent laryngeal cancer when surgery is not an option was first proposed by CC Wang (IJROBP 1993;26:783-5). He reported reasonable local control rates and stated, at the conclusion of “Radiation Therapy Results” in his paper, that “significant radiation sequelae… were not encoun...

I agree with the excellent answers above. To my knowledge, the MIRI data is the only data to directly compare SBRT and IMRT-based re-irradiation to date. All the caveats of retrospective multi-institution data apply. We tried to adjust for potential biases using two methods. After all of this, the t...

I would be very reluctant for retaliation with SBRT as published data shows very high risk of late effects in survivors

https://www.ncbi.nlm.nih.gov/pubmed/27302512