How would you manage severe Factor XII deficiency in a patient with recurrent pregnancy loss?

A causal relationship between factor XII deficiency and thrombophilia or recurrent pregnancy loss has not been firmly established. Although some studies have shown low factor XII levels in a relatively high proportion of individuals with recurrent pregnancy loss, it is not possible to exclude ascertainment bias as an explanation for these findings. Furthermore, trials have shown no evidence of benefit for antithrombotic therapy in individuals with known inherited thrombophilia and recurrent preg...