How would your management change for high-risk prostate cancer in a patient who is not a surgical candidate (due to age or medical comorbidities) and had prior pelvic irradiation?

Thank you for your question. Indeed, much of the data on re-irradiation in the pelvis corresponds to recurrent disease in GI or GYN malignancies. Historically, many physicians would recommend androgen deprivation alone as management in the setting of high risk prostate cancer with prior pelvic RT. H...