If an anatomical defect forms due to rapid disease response from pelvic radiation for large gynecological tumors, is it safe to proceed with a further radiotherapy boost?

How would you proceed, if defect would be part of your planned target with no gross residual and is adjacent to bladder or rectum.

• Treat now with brachytherapy independent of defect (may carry higher toxicity).
• Treat now with SBRT independent of defect.
• Wait some time until defect heals and if it heals proceed with brachy
• Leave as is and closely monitor until recurrence (very high risk for recurrence, but likely safer).
• Other