If you’re transitioning laterally between biologic classes due to adverse effects, do you repeat the loading dose?

I do usually repeat the loading dose when starting a new biologic, even if in the same class. If there is data on whether or not you should do this, I am not aware of it.

It depends on how much psoriasis burden the patient has when making the switch. When the patient has been cleared or mostly cleared by the biologic currently about to be discontinued, I will go onto maintenance dose with the next. If the patient has not responded well to the current treatment to be ...

Agree--even within classes, there are differences in the MOA and specific targets (area of protein, etc). It would indeed be nice to have data!