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Radiation Oncology • Genitourinary Cancers
In a patient with biochemical recurrence after radical prostatectomy (pathologic stage pT2, negative margins [R0], no bladder invasion, Gleason Grade Group 2) and a high-risk Decipher genomic classifier, with a PSA of 0.7 ng/mL, is there a rationale for administering salvage radiation therapy to the prostate fossa?
Radiation Oncologist
Yes, salvage RT to the prostate fossa (+ ADT/ pelvic lymph nodes) would be considered the a preferred option in this circumstance in my opinion (see NCCN 2026.3). Despite the PSA being higher than is typical in 2026 and some risk factors for not responding to RT (e.g., margin-negative resection), it...
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