In light of the cosmesis and toxicity outcomes of the RAPID trial, should external beam partial breast irradiation be avoided?

The results of RAPID trial does raise the concern about worse cosmetic results which may not have been captured by the CTCAE score used in the NSABP study and one should be very cautious in using this schedule outside the context of a clinical trial. Whether it was because of spillover dose to uninv...

The RAPID trial results are certainly provocative...this study was very well done indeed. 2135 women were randomized to either EB PBI or whole breast RT (no boost). Those treated with EB PBI had inferior cosmesis and marginally higher rates of grade 2 fibrosis. However, we should contrast these resu...