In what scenarios would you incorporate platinum for patients with localized TNBC?

Topics: Breast Cancer • Medical Oncology • Triple negative

How does gBRCA status impact your decision?

Answer from: Medical Oncologist at Academic Institution

In the neoadjuvant setting, I include a platinum - specifically carboplatin - in the chemo regimen in essentially all patients with TNBC. Not only have 3 randomized studies (CALGB 40603, BrighTNess and GeparSixto) demonstrated significantly higher pCR rates with addition of carboplatin, if you look ...

Answer from: Medical Oncologist at Community Practice

@William M. Sikov has thoughtfully presented an evidence based case for incorporating platinum in the management of localized TNBC. However, I believe incorporation of platinum in the management of localized TNBC remains controversial and should be individualized and reserved for patients with the h...

Comments

Medical Oncologist at Warren Alpert Medical School of Brown University
I respectfully disagree, and believe that stage II...

Medical Oncologist at University of Iowa Holden Comprehensive Cancer Center
We all are hopeful that improvement in pCR seen by...

Medical Oncologist at Warren Alpert Medical School of Brown University
TNBC patients who achieve pCR with the addition of...

Answer from: Medical Oncologist at Community Practice

On the question of identifying biomarkers for response to platinum, neither germline/tumor BRCA status, nor identifiers of BRCANess like HRD assay have been shown to be conclusive. The BrighTNess and GeparSixto studies reported no significant interactions between BRCA mutation status and treatment ...

Comments

Medical Oncologist at Alvin & Lois Lapidus Cancer Institute Northwest Hospital
Question for @William M. Sikov: Since the wild typ...

Medical Oncologist at Warren Alpert Medical School of Brown University
None of the studies was large enough to demonstrat...

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