In women with cN0 breast cancer who receive neoadjuvant chemotherapy due to other high-risk features, how does the finding of treatment effect in a post-chemo sentinel lymph node affect your radiation recommendations?

The answer is not known and I am sure practice pattern varies. Our decision to treat regional nodes is usually based on the number of sentinel nodes dissected (the negative predictive value of residual disease in the axilla is a function of the number of nodes and the use of dual tracer in clinicall...