Is it necessary to hold immunotherapy during a 4-6wk steroid taper after resolution of immunotherapy related toxicity?

Topics: Melanoma/Skin Cancer • Thoracic Malignancies • Medical Oncology • Immunotherapy • Biologic Therapy/Immunobiology

Would you ever considering re-starting immunotherapy before completing the taper?

According to the new guildelines on managing immunotherapy related toxicity created by the Society for Immunotherapy of Cancer (SITC) Toxicity, cases where steroids are started and the toxicity resolves, a 4-6wk steroid taper should be pursued and immunotx held until steroids are completely off. https://jitc.biomedcentral.com/articles/10.1186/s40425-017-0300-z

Answer from: Medical Oncologist at Community Practice

This is an excellent question. Most of the clinical trials with checkpoint inhibitors required complete taper of steroids prior to rechallenging wtih immunotherapy following toxicity. As we use immunotherapy in the clinic, and have utilized combinations with chemotherapy, including regim...

Comments

Medical Oncologist at Ralph Lauren Center for Cancer Care and Prevention
Very helpful! Thank you for your quick reply!

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