Is it necessary to hold immunotherapy during a 4-6wk steroid taper after resolution of immunotherapy related toxicity?
Would you ever considering re-starting immunotherapy before completing the taper?
According to the new guildelines on managing immunotherapy related toxicity created by the Society for Immunotherapy of Cancer (SITC) Toxicity, cases where steroids are started and the toxicity resolves, a 4-6wk steroid taper should be pursued and immunotx held until steroids are completely off. https://jitc.biomedcentral.com/articles/10.1186/s40425-017-0300-z
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Do you complete a full steroid taper prior to re-challenging with immunotherapy after a hold for toxicity?
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1 Answer
Mednet MemberInvited Expert
Medical Oncology · Cedars-Sinai Medical Center
Answered on
This is an excellent question. Most of the clinical trials with checkpoint inhibitors required complete taper of steroids prior to rechallenging wtih immunotherapy following toxicity. As we use immunotherapy in the clinic, and have utilized combinations with chemotherapy, including regimens that use...
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