Is lithium-induced hypothyroidism typically due to the production of autoimmune Hashimoto's antibodies or to the disruption of thyroid hormone production?

The answer is both. Lithium-induced hypothyroidism occurs in about 15% of patients treated with lithium. Lithium is concentrated 2-3 times higher than in serum due to uptake by the sodium iodide transporter. Hypothyroidism, in part, is due to lithium interrupting thyroid hormone production and relea...