Is the criteria for RT + PCV for low grade glioma too narrow?

This is an excellent question, which unfortunately does not have a straightforward answer. The first and obvious answer is that 9802 evaluated patients older than 40 or less than 40 only if they had a subtotal resection, and therefore the specific benefit of RT+PCV in those less than 40 with a GTR c...

The issue with low risk and high risk is not progression free survival as they appear to be very similar in RTOG 9802 but overall survival which is significantly lower for high risk in comparison to low risk. The end point for adding chemo is improving survival and not progression free survival and ...

We do not know the answer to your question with certainly. It has been felt for years that the biology of “low grade glioma” becomes more aggressive with age. Age of 40 years or 50 years is a statistical cut-off. For a 35-year old with complete resection, most people would observe and use surgery =R...